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All Journal Agrointek Communications in Science and Technology Jurnal Agroekoteknologi dan Agribisnis
David Septian Sumanto Marpaung
Institut Teknologi Sumatera
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Engineering

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Journal : Communications in Science and Technology

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A mini review on production of pluripotency factors (Oct4, Sox2, Klf4 and c-Myc) through recombinant protein technology David Septian Sumanto Marpaung; Ayu Oshin Yap Sinaga
Communications in Science and Technology Vol 5 No 1 (2020)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (538.566 KB) | DOI: 10.21924/cst.5.1.2020.171

Abstract

The four transcription factors OCT4, SOX2, KLF4 and c-MYC are highly expressed in embryonic stem cells (ESC) and their overexpression can induce pluripotency, the ability to differentiate into all cell types of an organism. The ectopic expression such transcription factors could reprogram somatic stem cells become induced pluripotency stem cells (iPSC), an embryonic stem cells-like. Production of recombinant pluripotency factors gain interests due to high demand from generation of induced pluripotent stem cells in regenerative medical therapy recently. This review will focus on demonstrate the recent advances in recombinant pluripotency factor production using various host.
Co-Authors Ayu Oshin Yap Sinaga Via Rahmatul Ummah